Anticonvulsant and GABA uptake inhibition properties of venom fractions from the spiders Parawixia bistriata and Scaptocosa raptoria

Anticonvulsant and GABA uptake inhibition properties of venom fractions from the spiders Parawixia bistriata and Scaptocosa raptoria

Author Cairrao, MAR Google Scholar
Ribeiro, A. M. Google Scholar
Pizzo, A. B. Google Scholar
Fontana, ACK Google Scholar
Beleboni, R. O. Google Scholar
Coutinho-Netto, J. Google Scholar
Miranda, A. Google Scholar
Santos, W. F. Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract In this article we describe an in vivo anticonvulsant effect from denatured crude venom and partially isolated fractions from two spiders: Parawixia bistriata and Scaptocosa raptoria. Intracerebroventricular injections of these venoms and fractions abolished rat convulsive tonic-clonic seizures induced by picrotoxin, bicuculline and pentylenetetrazole, and also, inhibited GABA uptake in synaptosomes of rat cerebral cortex. the venoms described in this work seems to be promising tools for the study of the GABAergic system, and may be a potential source for new anticonvulsant drugs.
Keywords anticonvulsant
bicuculline
GABA
GABA uptake
Parawixia bistriata
pentilenetetrazole
picrotoxin
Scaptocosa raptoria
spider venom
rat synaptosomes
Language English
Date 2002-09-01
Published in Pharmaceutical Biology. Lisse: Swets Zeitlinger Publishers, v. 40, n. 6, p. 472-477, 2002.
ISSN 1388-0209 (Sherpa/Romeo, impact factor)
Publisher Swets Zeitlinger Publishers
Extent 472-477
Origin http://dx.doi.org/10.1076/phbi.40.6.472.8436
Access rights Closed access
Type Article
Web of Science ID WOS:000179940300014
URI http://repositorio.unifesp.br/handle/11600/26969

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