Effects of melatonin on orofacial movements in rats

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dc.contributor.author Abilio, V. C.
dc.contributor.author Vera, JAR
dc.contributor.author Ferreira, LSM
dc.contributor.author Duarte, CRM
dc.contributor.author Carvalho, R. C.
dc.contributor.author Grassl, C.
dc.contributor.author Martins, C. R.
dc.contributor.author Torres-Leite, D.
dc.contributor.author Bignotto, M.
dc.contributor.author Tufik, S.
dc.contributor.author Ribeiro, R. D.
dc.contributor.author Frussa, R.
dc.date.accessioned 2016-01-24T12:33:24Z
dc.date.available 2016-01-24T12:33:24Z
dc.date.issued 2002-06-01
dc.identifier http://dx.doi.org/10.1007/s00213-002-1081-7
dc.identifier.citation Psychopharmacology. New York: Springer-verlag, v. 161, n. 4, p. 340-347, 2002.
dc.identifier.issn 0033-3158
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/26880
dc.description.abstract Rationale: While reserpine-induced oral movements (OM), an animal model of tardive dyskinesia, are more persistent in old than in adult rats, old animals present spontaneous OM, which are phenomenologically similar to those presented by reserpine-treated adult rats. We postulate that these OM may be the result of oxidative stress induced by both age and reserpine treatment. Objectives: We intended to determine the preventative effects of exogenous melatonin (one of the most important endogenous antioxidants) as well as suppression of endogenous melatonin via continuous exposure to light on reserpine- or age-induced OM in rats. Methods: Adult (4 months of age) male Wistar rats were repeatedly treated with saline or melatonin (5 mg/kg, IP) and saline or reserpine and kept under a 12-h light/dark cycle for quantification of reserpine-induced OM as well as oxidative stress (via quantification of lipid peroxidation). To verify the effects of endogenous melatonin suppression on reserpine-induced OM, adult rats were repeatedly treated with saline or reserpine and continuously exposed to light. To verify the effects of exogenous melatonin on age-induced OM older (20 months of age) rats were long-term treated with saline or melatonin and kept under a 12-h light/dark cycle. Results: Melatonin attenuated both reserpine- and age-induced OM. Reserpine enhanced striatal lipid peroxidation, that was prevented by melatonin co-administration. Continuous exposure to light increased spontaneous as well as reserpine-induced OM, indicating that endogenous melatonin may be involved in this movement disorder. Conclusions: We suggested that melatonin attenuates both reserpine- and age-induced OM in rats. en
dc.format.extent 340-347
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof Psychopharmacology
dc.rights Acesso restrito
dc.subject melatonin en
dc.subject dopamine en
dc.subject orofacial movement en
dc.subject tardive dyskinesia en
dc.subject oxidative stress en
dc.subject aging en
dc.title Effects of melatonin on orofacial movements in rats en
dc.type Artigo
dc.rights.license http://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med, Dept Pharmacol, BR-04023062 São Paulo, Brazil
dc.description.affiliation UNIFESP, Escola Paulista Med, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med, Dept Pharmacol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifesp UNIFESP, Escola Paulista Med, Dept Psychobiol, São Paulo, Brazil
dc.identifier.doi 10.1007/s00213-002-1081-7
dc.description.source Web of Science
dc.identifier.wos WOS:000176573300002



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