The mitochondrial toxin 3-nitropropionic acid aggravates reserpine-induced oral dyskinesia in rats

The mitochondrial toxin 3-nitropropionic acid aggravates reserpine-induced oral dyskinesia in rats

Author Calvente, PRV Google Scholar
Araujo, CCS Google Scholar
Bergamo, M. Google Scholar
Abilio, V. C. Google Scholar
D'Almeida, V Google Scholar
Ribeiro, RDA Google Scholar
Frussa, R. Google Scholar
Institution Dept Farmacol
Universidade Federal de São Paulo (UNIFESP)
Abstract The effects of a previous long-term administration of the mitochondrial toxin 3-nitropropionic acid were studied on an animal model of tardive dyskinesia, i.e., die frequency of spontaneous tongue protrusions in rats repeatedly treated with reserpine. 3-Nitropropionic acid (10 or 15 mg/kg ip, every other day for 17 days) potentiated the increase in tongue-protrusion frequency induced by reserpine (1 mg/kg, sc, every other day for 3 days) but did not modify reserpine-induced increase in immobility duration and decrease in locomotion frequency. These results support the notion that neurotoxic events are associated with the development of tardive dyskinesia. (C) 2001 Elsevier Science Inc. All rights reserved.
Keywords rat
reserpine
tardive dyskinesia
tongue protrusion
3-nitropropionic acid
Language English
Date 2002-02-01
Published in Progress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 26, n. 2, p. 401-405, 2002.
ISSN 0278-5846 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 401-405
Origin http://dx.doi.org/10.1016/S0278-5846(01)00255-X
Access rights Closed access
Type Review
Web of Science ID WOS:000173005700028
URI http://repositorio.unifesp.br/handle/11600/26749

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