Susceptibility profile of vaginal yeast isolates from Brazil

Susceptibility profile of vaginal yeast isolates from Brazil

Author Ribeiro, M. A. Google Scholar
Dietze, R. Google Scholar
Paula, C. R. Google Scholar
Matta, Daniel Archimedes da Autor UNIFESP Google Scholar
Colombo, A. L. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Fed Espirito Santo
Universidade de São Paulo (USP)
Abstract Vaginal specimens for culture were obtained from two hundred and five immunocompetent, non-hospitalized patients selected among all women attending the Gynecology and Obstetric Ambulatory Clinic of the University of Espirito Santo, Brazil, during a 2-year period (From 1998 to 1999). Patients were checked for signs and symptoms of vulvovaginitis and previous use of topical and systemic antifungal drugs. Yeast isolates were identified by classical methods and the antifungal susceptibility profile was determined according to NCCLS microbroth assay.The prevalence of vaginal yeast isolates from asymptomatic women was 25% (30/121) and 60% (50/84) among patients with symptoms of vulvovaginitis. Candida albicans was the most frequently isolated species in both groups (46% and 90%, respectively), followed by C. glabrata (13% and 6%, respectively). All isolates were susceptible to amphotericin B. Only ten isolates had dose dependent susceptibility (DDS) or resistance to azoles; and seven of these were non-albicans species.Based on our results we suggest that species identification and antifungal susceptibility testing need not be routinely performed in immunocompetent women, and may be reasonable only for the minority of patients with complicated vulvovaginal candidiasis that fail to respond to therapy.
Keywords antifungal susceptibility
Candida spp.
vaginitis
Language English
Date 2001-01-01
Published in Mycopathologia. Dordrecht: Kluwer Academic Publ, v. 151, n. 1, p. 5-10, 2001.
ISSN 0301-486X (Sherpa/Romeo, impact factor)
Publisher Kluwer Academic Publ
Extent 5-10
Origin http://dx.doi.org/10.1023/A:1010909504071
Access rights Closed access
Type Article
Web of Science ID WOS:000169517200003
URI http://repositorio.unifesp.br/handle/11600/26450

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