Receptors coupling to G proteins: Is there a signal behind the sequence?

Receptors coupling to G proteins: Is there a signal behind the sequence?

Author Horn, F. Google Scholar
van der Wenden, E. M. Google Scholar
Oliveira, Laerte Autor UNIFESP Google Scholar
IJzerman, A. P. Google Scholar
Vriend, Gerrit Google Scholar
Institution CMBI
European Mol Biol Lab
Leiden Univ
Universidade Federal de São Paulo (UNIFESP)
Abstract Upon the binding of their ligands, G protein-coupled receptors couple to the heterotrimeric G proteins to transduce a signal. One receptor family may couple to a single G protein subtype and another family to several ones. Is there a signal in the receptor sequence that can give an indication of the G protein subtype selectivity? We used a sequence analysis method on biogenic amine and adenosine receptors and concluded that a weak signal can be detected in receptor families where specialization for coupling to a given G protein occurred during a recent divergent evolutionary process. Proteins 2000;41:448-459. (C) 2000 Wiley-Liss, Inc.
Keywords receptor
GPCR
G protein selectivity
correlated mutations
sequence analysis
Language English
Date 2000-12-01
Published in Proteins-structure Function and Genetics. New York: Wiley-liss, v. 41, n. 4, p. 448-459, 2000.
ISSN 0887-3585 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 448-459
Origin http://dx.doi.org/10.1002/1097-0134(20001201)41:4<448
Access rights Closed access
Type Review
Web of Science ID WOS:000165365500003
URI http://repositorio.unifesp.br/handle/11600/26421

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