A double-blind, comparative, placebo-controlled study of the efficacy and tolerability of 4% hydroquinone as a depigmenting agent in melasma

A double-blind, comparative, placebo-controlled study of the efficacy and tolerability of 4% hydroquinone as a depigmenting agent in melasma

Author Ennes, SBP Google Scholar
Paschoalick, R. C. Google Scholar
Alchorne, Maurício Mota de Avelar Autor UNIFESP Google Scholar
Institution Univ Mogi Cruzes
Universidade Federal de São Paulo (UNIFESP)
Abstract AIM: the objective of this study was to evaluate the efficacy and tolerability of hydroquinone 4% cream with sunscreens, controlled by placebo, in the treatment of melasma,METHODS: A total of 48 patients were randomly chosen, 24 in the hydroquinone 4% group and 24 in the placebo group. Patients were instructed to use and apply additional sunscreen. the treatment lasted 12 weeks, with an evaluation of efficacy, tolerability and photographs taken every 3 weeks, Efficacy was classified as 'total improvement', 'partial improvement' or 'failure', Tolerability was classified as 'excellent', 'good', 'fair' or 'poor',RESULTS: the difference between the efficacy of the hydroquinone 4% and placebo groups was statistically significant, in the hydroquinone group, 40% of the patients showed complete disappearance of spots at the end of the treatment and there was no therapeutic failure reported. in the placebo group, 10% of the patients showed 'total improvement' and therapeutic failures occurred in 20% of the patients. Both treatments were well tolerated, with no serious adverse events reported.CONCLUSIONS: the results indicate that hydroquinone 4% is a safe and effective drug for the treatment of melasma and that sunscreens are important as concomitant treatment by way of preventing repigmentation and improving skill appearance.
Keywords chloasma
depigmenting
hydroquinone
melasma sunscreen
Language English
Date 2000-09-01
Published in Journal of Dermatological Treatment. London: Martin Dunitz Ltd, v. 11, n. 3, p. 173-179, 2000.
ISSN 0954-6634 (Sherpa/Romeo, impact factor)
Publisher Martin Dunitz Ltd
Extent 173-179
Origin http://dx.doi.org/10.1080/09546630050517333
Access rights Closed access
Type Article
Web of Science ID WOS:000089945800008
URI http://repositorio.unifesp.br/handle/11600/26380

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