Distribution of sulfated glycosaminoglycans in the animal kingdom: widespread occurrence of heparin-like compounds in invertebrates

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dc.contributor.author Medeiros, G. F.
dc.contributor.author Mendes, A.
dc.contributor.author Castro, RAB
dc.contributor.author Bau, E. C.
dc.contributor.author Nader, H. B.
dc.contributor.author Dietrich, C. P.
dc.date.accessioned 2016-01-24T12:31:08Z
dc.date.available 2016-01-24T12:31:08Z
dc.date.issued 2000-07-26
dc.identifier http://dx.doi.org/10.1016/S0304-4165(00)00079-9
dc.identifier.citation Biochimica Et Biophysica Acta-general Subjects. Amsterdam: Elsevier B.V., v. 1475, n. 3, p. 287-294, 2000.
dc.identifier.issn 0304-4165
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/26347
dc.description.abstract Sulfated glycosaminoglycans were isolated from 23 species of 13 phyla of invertebrates and characterized by their electrophoretic migration in three different buffer systems coupled with enzymatic degradation using bacterial heparinase, heparitinases and chondroitinase AC. Heparan sulfate is a ubiquitous compound present in all species analyzed whereas chondroitin sulfate was present in 20 species and heparin-like compounds in 12 species of the invertebrates. the heparin-like compounds were purified from the echinoderm Mellita quinquisperforata (sand dollar) and the crustacean Ucides cordatus (crab) with anticoagulant activities of 60 and 52 IU/mg, respectively. Degradation of these heparins with heparinase produced significant amounts of the trisulfated disaccharide typical of mammalian heparins. This was confirmed by C-13-NMR spectroscopy of the crab heparin. An updated phylogenetic tree of the distribution of sulfated glycosaminoglycans in the animal kingdom is also presented. (C) 2000 Elsevier Science B.V. All rights reserved. en
dc.format.extent 287-294
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Biochimica Et Biophysica Acta-general Subjects
dc.rights Acesso restrito
dc.subject sulfated glycosaminoglycan distribution en
dc.subject sulfated glycosaminoglycan en
dc.subject invertebrate en
dc.subject heparan sulfate en
dc.subject chondroitin sulfate en
dc.subject heparin en
dc.title Distribution of sulfated glycosaminoglycans in the animal kingdom: widespread occurrence of heparin-like compounds in invertebrates en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Univ Fed Rio Grande Norte
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med, Dept Bioquim, BR-04044020 São Paulo, Brazil
dc.description.affiliation Univ Fed Rio Grande Norte, Dept Bioquim, BR-59072970 Natal, RN, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med, Dept Bioquim, BR-04044020 São Paulo, Brazil
dc.identifier.doi 10.1016/S0304-4165(00)00079-9
dc.description.source Web of Science
dc.identifier.wos WOS:000088518000012



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