Effects of buspirone on an animal model of tardive dyskinesia

Effects of buspirone on an animal model of tardive dyskinesia

Author Queiroz, CMT Google Scholar
Frussa-Filho, R. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract 1. the effects of buspirone were studied on an animal model of tardive dyskinesia, i.e., the quantification of orofacial dyskinesia in rats repeatedly treated with reserpine.2. Rats were co-treated with saline [SAL] or buspirone [BUS] (3.0 mg/kg, i.p., twice daily) and vehicle [VEH] or reserpine [RES] (0.1 mg/kg, s.c., once every other day) for 19 days. On the day 20, the animals were observed for quantification of the behavioral parameters of orofacial dyskinesia: tongue protrusion and vacuous chewing movements frequencies and duration of twitching of the facial musculature.3. Rats of the SAL+RES group exhibited a significant increase in the three behavioral parameters of orofacial dyskinesia relative to the rats of the SAL+VEH group. However, animals of the BUS+RES group showed only an increased frequency of vacuous chewing movements when compared to animals of the SAL+VEH group. in addition, the duration of the facial twitching was significantly decreased in the BUS+RES group in relation to rats of the SAL+RES group. There were no significant differences in the orofacial parameters between the BUS+VEH and the SAL+VEH groups.4. Because it was also verified that chronic buspirone treatment was able to increase apomorphine-induced yawning behavior, the possibility is raised that buspirone attenuates reserpine-induced orofacial dyskinesia through the development of dopamine autoreceptor supersensitivity.
Keywords buspirone
dopamine
orofacial movements
rat
reserpine
serotonin
tardive dyskinesia
Language English
Date 1999-11-01
Published in Progress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 23, n. 8, p. 1405-1418, 1999.
ISSN 0278-5846 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 1405-1418
Origin http://dx.doi.org/10.1016/S0278-5846(99)00074-3
Access rights Closed access
Type Review
Web of Science ID WOS:000083628500007
URI http://repositorio.unifesp.br/handle/11600/26170

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