Distribution and composition of glycosaminoglycans in the left human coronary arterial branches under myocardial bridge

Distribution and composition of glycosaminoglycans in the left human coronary arterial branches under myocardial bridge

Author Shinjo, Samuel K. Autor UNIFESP Google Scholar
Prates, Nadir EVB Google Scholar
Oba, Sueli M. Autor UNIFESP Google Scholar
Sampaio, Lúcia O. Autor UNIFESP Google Scholar
Nader, Helena B. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract The distribution and composition of glycosaminoglycans (GAGs) are reported in the anterior interventricular branch under the intermyocardial bridge (MB) and the ventricular branch without bridge, both from the left human coronary artery. Chondroitin sulfate (CS), dermatan sulfate (DS) and heparan sulfate (HS) were purified and quantified by a combination of electrophoretic migration and enzymatic degradation. the absolute amounts of GAGs in the intermyocardial bridge segment (MB) increased by 47%, when compared to the pre (PreMB) and post (PostMB) segments and the ventricular arterial branch (VB). Furthermore, the relative distribution of GAGs in the intermyocardial bridge segment differs when compared to the pre and post segments as well as in the ventricular arterial branch, due to a change in the proportion of DS and CS of 41.9 and 32.4%, compared to 36.4 and 39.7%, respectively. These findings give support to the possible involvement of GAGs in the intermyocardial bridge segment, avoiding local thrombus deposition, reducing atherosclerotic development and moreover giving protection against vessel deformation caused by the systolic pressure. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
Keywords glycosaminoglycans
heparan sulfate
chondroitin sulfate
human coronary artery
myocardial bridge
Language English
Date 1999-04-01
Published in Atherosclerosis. Clare: Elsevier Sci Ireland Ltd, v. 143, n. 2, p. 363-368, 1999.
ISSN 0021-9150 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 363-368
Origin http://dx.doi.org/10.1016/S0021-9150(98)00323-2
Access rights Closed access
Type Article
Web of Science ID WOS:000079595800015
URI http://repositorio.unifesp.br/handle/11600/26055

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