C-erbB-2 immunoexpression in parathyroid tumors and hyperplasias

C-erbB-2 immunoexpression in parathyroid tumors and hyperplasias

Author Kayath, M. J. Google Scholar
Martin, L. C. Google Scholar
Vieira, JGH Google Scholar
Nose, V Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract C-erbB-2 is a proto-oncogene previously implicated in the pathogenesis and prognosis of several human tumors. the authors investigated c-erbB-2 immunoexpression in parathyroid tumors and hyperplasias, and correlated its presence with the diagnosis and severity of the parathyroid lesions. One hundred two parathyroid tissues (28 adenomas, 12 primary hyperplasias, 57 secondary hyperplasias, and 5 carcinomatous tissues) were studied. Membrane c-erbB-2 (either in the cell membrane or on the border of pseudocysts) was absent in normal glands, and detected in 50% of the adenomas, 25% of the primary hyperplasias, 100% of the carcinomas, and 12 and 53% of the secondarily diffuse and nodular hyperplasias, respectively. C-erbB-2 expression was significantly lower in diffuse hyperplasias than in other parathyroid lesions (P < 0.05). Cytoplasmic c-erbB-2 expression (restricted to oxyphil cells) was found in 50% of the normal tissues and in variable frequency in parathyroid lesions. Mean gland mass and intact parathyroid hormone levels were not significantly different according to c-erbB-2 immunodetection. Mean serum ionized calcium was higher in c-erbB-2-positive adenomas than in negative ones (P = 0.006). in conclusion, c-erbB-2 protein is frequently detected in hyperproliferative conditions of the parathyroid, such as neoplasms and hyperplasias.
Keywords parathyroid neoplasms
c :-erbB-2
hyperparathyroidism
Language English
Date 1999-03-01
Published in Endocrine Pathology. Totowa: Humana Press Inc, v. 10, n. 1, p. 47-54, 1999.
ISSN 1046-3976 (Sherpa/Romeo, impact factor)
Publisher Humana Press Inc
Extent 47-54
Origin http://dx.doi.org/10.1007/BF02738815
Access rights Closed access
Type Article
Web of Science ID WOS:000079906100006
URI http://repositorio.unifesp.br/handle/11600/26039

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