Nephrotic syndrome as a clinical manifestation of graft-versus-host disease (GVHD) in a marrow transplant recipient after cyclosporine withdrawal

Nephrotic syndrome as a clinical manifestation of graft-versus-host disease (GVHD) in a marrow transplant recipient after cyclosporine withdrawal

Author Oliveira, José Salvador Rodrigues de Autor UNIFESP Google Scholar
Bahia, Daniella Marcia Maranhão Autor UNIFESP Google Scholar
Franco, Marcello Fabiano de Autor UNIFESP Google Scholar
Balda, C. Google Scholar
Stella, S. Google Scholar
Kerbauy, José Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract GVHD is one of the most frequent complications of BMT and recently nephrotic syndrome (NS) has been described as a manifestation of chronic GVHD, Here, we present an AA patient who developed NS 1 year after BMT when cyclosporine was stopped. Renal biopsy showed focal sclerosis associated with membranous deposits. He also had other clinical manifestations of chronic GVHD: sicca-like syndrome and colestasis, After 15 days of CsA therapy, he experienced a remarkable improvement in the NS and GVHD as a whole. We comment on immunological mechanisms that could be involved in the pathogenesis of this manifestation.
Keywords nephrotic syndrome
bone marrow transplant
GVHD
Language English
Date 1999-01-01
Published in Bone Marrow Transplantation. Basingstoke: Stockton Press, v. 23, n. 1, p. 99-101, 1999.
ISSN 0268-3369 (Sherpa/Romeo, impact factor)
Publisher Stockton Press
Extent 99-101
Origin http://dx.doi.org/10.1038/sj.bmt.1701527
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000078318800017
URI http://repositorio.unifesp.br/handle/11600/25998

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