Reserpine does not induce orofacial dyskinesia in spontaneously hypertensive rats

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dc.contributor.author Queiroz, CMT
dc.contributor.author Piovezan, R. D.
dc.contributor.author Frussa-Filho, R.
dc.date.accessioned 2016-01-24T12:30:39Z
dc.date.available 2016-01-24T12:30:39Z
dc.date.issued 1998-09-04
dc.identifier http://dx.doi.org/10.1016/S0014-2999(98)00546-9
dc.identifier.citation European Journal of Pharmacology. Amsterdam: Elsevier B.V., v. 356, n. 2-3, p. 105-108, 1998.
dc.identifier.issn 0014-2999
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/25957
dc.description.abstract The nigrostriatal dopaminergic system seems to be involved in both reserpine-induced orofacial dyskinesia in normal rats and in the pathogenesis of hypertension in spontaneously hypertensive rats. in the present study, repeated reserpine administration (1.0 mg/kg, s.c., every other day, for 3 days) increased tongue protrusion and vacuous chewing frequencies as well as the duration of facial twitching in Wistar normotensive but not in spontaneously hypertensive rats. These results suggest that genetic hypertension and drug-induced orofacial movements may be inversely modulated by similar mechanisms in the nigrostriatal dopaminergic system. (C) 1998 Elsevier Science B.V. All rights reserved. en
dc.format.extent 105-108
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof European Journal of Pharmacology
dc.rights Acesso restrito
dc.subject reserpine en
dc.subject spontaneously hypertensive rat (SHR) en
dc.subject orofacial dyskinesia en
dc.subject tardive dyskinesia en
dc.subject dopamine en
dc.title Reserpine does not induce orofacial dyskinesia in spontaneously hypertensive rats en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med, Dept Farmacol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med, Dept Farmacol, BR-04023062 São Paulo, Brazil
dc.identifier.doi 10.1016/S0014-2999(98)00546-9
dc.description.source Web of Science
dc.identifier.wos WOS:000076065500002



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