Reserpine does not induce orofacial dyskinesia in spontaneously hypertensive rats

Reserpine does not induce orofacial dyskinesia in spontaneously hypertensive rats

Author Queiroz, CMT Google Scholar
Piovezan, R. D. Google Scholar
Frussa-Filho, R. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract The nigrostriatal dopaminergic system seems to be involved in both reserpine-induced orofacial dyskinesia in normal rats and in the pathogenesis of hypertension in spontaneously hypertensive rats. in the present study, repeated reserpine administration (1.0 mg/kg, s.c., every other day, for 3 days) increased tongue protrusion and vacuous chewing frequencies as well as the duration of facial twitching in Wistar normotensive but not in spontaneously hypertensive rats. These results suggest that genetic hypertension and drug-induced orofacial movements may be inversely modulated by similar mechanisms in the nigrostriatal dopaminergic system. (C) 1998 Elsevier Science B.V. All rights reserved.
Keywords reserpine
spontaneously hypertensive rat (SHR)
orofacial dyskinesia
tardive dyskinesia
dopamine
Language English
Date 1998-09-04
Published in European Journal of Pharmacology. Amsterdam: Elsevier B.V., v. 356, n. 2-3, p. 105-108, 1998.
ISSN 0014-2999 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 105-108
Origin http://dx.doi.org/10.1016/S0014-2999(98)00546-9
Access rights Closed access
Type Article
Web of Science ID WOS:000076065500002
URI http://repositorio.unifesp.br/handle/11600/25957

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