Ultrastructural and lanthanum tracer examination of rapidly resorbing rat alveolar bone suggests that osteoclasts internalize dying bone cells

Ultrastructural and lanthanum tracer examination of rapidly resorbing rat alveolar bone suggests that osteoclasts internalize dying bone cells

Author Taniwaki, N. N. Google Scholar
Katchburian, E. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
AdolfoLutz Inst
Abstract Glutaraldehyde-formaldehyde fixed undecalcified alveolar bone from 7-day-old rats was prepared for light and electron microscopy. Colloidal lanthanum was used as an ultrastructural tracer, and both random and semi-serial sections were examined. Lanthanum penetrated the infoldings of the ruffled border and some nearby vacuoles and vesicles. the majority of vacuoles and vesicles were lanthanum-free. Some osteoclast profiles contained a large vacuole with a cell enclosed in its interior. the enclosed cell exhibited an irregular nucleus containing condensed peripheral chromatin, intact cytoplasmic organelles, conspicuous rough endoplasmic reticulum and large blebs on the cell surface. These features are characteristic of osteoblasts or bone-lining cells or immature osteocytes which may be undergoing apoptosis or necrosis. the observation of remnants of cellular structures within internalized osteoclast vacuoles, together with the above results, suggests that osteoclasts engulf and probably degrade dying osteoblasts/bone-lining cells or immature osteocytes.
Keywords osteoclast
bone
bone resorption
alveolar bone
rat (Wistar)
Language English
Date 1998-07-01
Published in Cell and Tissue Research. New York: Springer Verlag, v. 293, n. 1, p. 173-176, 1998.
ISSN 0302-766X (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 173-176
Origin http://dx.doi.org/10.1007/s004410051109
Access rights Closed access
Type Article
Web of Science ID WOS:000075671800017
URI http://repositorio.unifesp.br/handle/11600/25924

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