Legume vicilins (7S storage globulins) inhibit yeast growth and glucose stimulated acidification of the medium by yeast cells

Legume vicilins (7S storage globulins) inhibit yeast growth and glucose stimulated acidification of the medium by yeast cells

Author Gomes, V. M. Google Scholar
Okorokov, L. A. Google Scholar
Rose, T. L. Google Scholar
Fernandes, KVS Google Scholar
Xavier-Filho, J. Google Scholar
Institution Univ Estadual Norte Fluminense
Universidade Federal de São Paulo (UNIFESP)
Univ Fed Ceara
Abstract Vicilin (7S storage proteins) isolated from different legume seeds were shown to inhibit yeast growth and glucose stimulated acidification of the medium by yeast cells. the degree of growth inhibition varied with the origin of vicilins. It was more than 90% for vicilins from cowpea (Vigna unguiculata, cultivar pitiuba) and equal to 65% for vicilins from Vigna radiata, in the case of Saccharomyces cerevisae. Vicilins from cowpea seeds inhibited the glucose stimulated acidification of the medium by S. cerevisae up to 60%. We have also observed that vicilins bind to yeast cells. We suggest that vicilins bind to chitin-containing structures of yeast cells and that such association could result in inhibition of H+ pumping, cell growth and spore formation. A final consequence of the yeast growth inhibition by vicilins is (probably) the formation of spores. (C) 1998 Elsevier Science B.V.
Keywords vicilin
7S storage protein
legume seed
chitin-binding protein
H+ pumping
(Saccharomyces cerevisae)
(Candida albicans)
(yeast)
Language English
Date 1998-02-02
Published in Biochimica Et Biophysica Acta-general Subjects. Amsterdam: Elsevier B.V., v. 1379, n. 2, p. 207-216, 1998.
ISSN 0304-4165 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 207-216
Origin http://dx.doi.org/10.1016/S0304-4165(97)00100-1
Access rights Closed access
Type Article
Web of Science ID WOS:000072285000006
URI http://repositorio.unifesp.br/handle/11600/25865

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