Ca2+ release-activated channels in rat stomach smooth muscle cells

Ca2+ release-activated channels in rat stomach smooth muscle cells

Author Smaili, Soraya Soubhi Autor UNIFESP Google Scholar
Cavalcanti, P. M. Google Scholar
Oshiro, MEM Google Scholar
Ferreira, A. T. Google Scholar
Jurkiewicz, A. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract In rat stomach fundus, contractions induced by Ca2+ (1.8 mM) were strikingly potentiated by thapsigargin. This potentiation was partially inhibited by the blockers of Ca2+ release activated channels (CRACs), miconazole and SK&F96365 ({1-[beta-[3-(4-methoxyphenyl)propoxy]-4- methoxyphenethyl]-1H-imidazole, HCL}) and slightly blocked by the antagonist of calcium voltage-operated channels (VOCs), isradipine. in dissociated cells in a 0Ca solution, thapsigargin potentiated the increase in intracellular calcium after reintroduction of Ca2+. This potentiation was partially reduced by the CRAC blockers, but not by the VOC blockers. This data suggests that calcium influx increased due to the depletion of intracellular calcium by thapsigargin and that this influx occurs predominantly through CRACs. (C) 1998 Elsevier Science B.V.
Keywords stomach fundus, rat
calcium store
isradipine
thapsigargin
SK & F96365
miconazole
Language English
Date 1998-01-19
Published in European Journal of Pharmacology. Amsterdam: Elsevier B.V., v. 342, n. 1, p. 119-122, 1998.
ISSN 0014-2999 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 119-122
Origin http://dx.doi.org/10.1016/S0014-2999(97)01537-9
Access rights Closed access
Type Article
Web of Science ID WOS:000072455900015
URI http://repositorio.unifesp.br/handle/11600/25856

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