Effects of monosialoganglioside on a new model of tardive dyskinesia

Effects of monosialoganglioside on a new model of tardive dyskinesia

Author Vital, MABF Google Scholar
Frussa, R. Google Scholar
PalermoNeto, J. Google Scholar
Institution Universidade de São Paulo (USP)
UNIV FED PARANA
Universidade Federal de São Paulo (UNIFESP)
Abstract 1- the effects of monosialoganglioside GM(1) were studied on a new model of tardive dyskinesia, i.e., the frequency of spontaneous tongue protrusions in rats repeatedly treated with reserpine.2- Rats were co-treated with vehicle (VEH) or reserpine (RES) (0.1 mg/kg, sc, every other day) and saline (SAL) or GM1 (5 mg/kg, ip, every day) for 30 days and observed for tongue protrusions on days 10, 20 and 30.3- During each test day animals of the RES+SAL, group exhibited an increase in tongue protrusions relative to rats of the VEH+SAL group. However, rats of the RES+GM(1) group showed an increased frequency of tongue protrusions only on day 10, when compared to animals of the VEH+SAL group. There were no significant differences in tongue protrusion frequency between the VEH+GM(1) and the VEH+SAL groups.4- These results differ from previous studies which reported a facilitatory effect of GM1 coadministration on conventional behavioral animal models of tardive dyskinesia: the possibility is raised that GM1 attenuates the reserpine-induced increase in tongue protrusions through its protective effect on glutamate/oxidative stress neurotoxicity.
Keywords gangliosides
GM(1)
reserpine
tardive dyskinesia
tongue protrusions
Language English
Date 1997-10-01
Published in Progress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 21, n. 7, p. 1169-1179, 1997.
ISSN 0278-5846 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 1169-1179
Origin http://dx.doi.org/10.1016/S0278-5846(97)00108-5
Access rights Closed access
Type Review
Web of Science ID WOS:A1997YD87700006
URI http://repositorio.unifesp.br/handle/11600/25793

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