STRUCTURAL and FUNCTIONAL-PROPERTIES of TRYPANOSOMA TRANS-SIALIDASE

STRUCTURAL and FUNCTIONAL-PROPERTIES of TRYPANOSOMA TRANS-SIALIDASE

Author Schenkman, S. Google Scholar
Eichinger, D. Google Scholar
Pereira, MEA Google Scholar
NUSSENZWEIG, V Google Scholar
Institution NYU
TUFTS UNIV
Universidade Federal de São Paulo (UNIFESP)
Abstract Sialic acids and sialidases play important roles in cellular interactions and modulate the recognition of pathogenic microbes by mammalian host cells. Protozoan parasites of the genus Trypanosoma express a unique sialic acid metabolizing enzyme. This enzyme, named trans-sialidase (TS), catalyzes the transfer of sialic acids from host glycoconjugates to acceptor molecules of the parasite plasma membrane. in African trypanosomes, the agents of sleeping sickness, TS is found only in forms developing within the insect vector, and the enzyme sialylates the major surface protein. in Trypanosoma cruzi, the causative agent of Chagas' disease in Central and South America, TS is expressed both in the insect and mammalian forms of the parasite. the T. cruzi enzyme has been biochemically characterized, and the gene encoding the enzyme has been cloned. the enzyme sialylates abundant mucin-like molecules present on the surface of the parasite. Several lines of evidence suggest that TS and sialic acid accepters on the surface of T. cruzi participate in host-parasite interactions and mediate the initial stages of the trypanosomes' invasion of host cells.
Keywords SIALIC ACIDS
CELL INVASION
MUCIN
SIALIDASE
OLIGOSACCHARIDE SYNTHESIS
Language English
Date 1994-01-01
Published in Annual Review of Microbiology. Palo Alto: Annual Reviews Inc, v. 48, p. 499-523, 1994.
ISSN 0066-4227 (Sherpa/Romeo, impact factor)
Publisher Annual Reviews Inc
Extent 499-523
Origin http://dx.doi.org/10.1146/annurev.mi.48.100194.002435
Access rights Closed access
Type Review
Web of Science ID WOS:A1994PM44600019
URI http://repositorio.unifesp.br/handle/11600/25382

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