Prognostic factors in laryngeal cancer patients submitted to surgical treatment

Prognostic factors in laryngeal cancer patients submitted to surgical treatment

Author Kowalski, Luiz Paulo Google Scholar
Franco, Eduardo L. Google Scholar
Andrade Sobrinho, Josias de Google Scholar
Oliveira, Benedito V. Google Scholar
Pontes, Paulo Autor UNIFESP Google Scholar
Institution Erasto Gaertner Hosp
Universidade Federal de São Paulo (UNIFESP)
Ludwig Inst Canc Res
Heliopolis Hosp
Abstract The authors studied some demographic, clinical, pathologic, and therapeutic variables in relation to the disease-free interval (DFI) and to the overall survival of laryngeal cancer patients. the patient population consisted of 278 consecutive cases of primary laryngeal cancer who had been admitted to four head and neck surgery services in São Paulo and Curitiba (Brazil) between 1973 and 1986. All patients had surgical treatment. Although several variables exhibited individual associations with survival, only a few were deemed to have independent prognostic value using multivariate regression techniques based on Cox's proportional hazards model. the primary tumor stage (T index) represented the variable with the highest predictive strength with respect to survival. Hazard ratios for the risk of disease recurrence were 2.3 (T2-3 vs. T1) and 4.3 (T4 vs. T1). Hazard ratios for the risk of death were 1.6 (T2-3 vs. T1) and 3.3 (T4 vs. T1). the following additional factors were also independently associated with the DFI: age, site of primary tumor (transglottic, glottic, or supraglottic), extracapsular spread of lymph node metastasis, surgical margins, type of paratracheal node dissection, and prior tracheostomy. Except for extracapsular spread, the same factors related to the DFI were also significantly related to the overall survival. Race, sex, N-stage, vascular embolization, and histological grade were other independent predictors of the risk of death.
Keywords Survival analysis
Disease-free interval
Head and Neck Surgery
Language English
Date 1991-10-01
Published in Journal of Surgical Oncology. New York: Wiley-liss, v. 48, n. 2, p. 87-95, 1991.
ISSN 0022-4790 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 87-95
Access rights Closed access
Type Article
Web of Science ID WOS:A1991GK46700003

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