An open multicenter study of the use of gatifloxacin for the treatment of non-complicated acute bacterial rhinosinusitis in adults

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dc.contributor.author Weckx, Luc Louis Maurice [UNIFESP]
dc.contributor.author Campos, C.a.h.
dc.contributor.author Sakano, Eulália
dc.contributor.author Pignatari, Shirley Shizue Nagata [UNIFESP]
dc.contributor.author Figueiredo, C.r. [UNIFESP]
dc.date.accessioned 2015-06-14T13:31:34Z
dc.date.available 2015-06-14T13:31:34Z
dc.date.issued 2005-04-01
dc.identifier http://dx.doi.org/10.1590/S1413-86702005000200007
dc.identifier.citation Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 9, n. 2, p. 162-168, 2005.
dc.identifier.issn 1413-8670
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/2509
dc.description.abstract The bacteriological and clinical efficacy and the safety of gatifloxacin for the treatment of non-complicated acute rhinosinusitis was evaluated in 49 adult patients in an open-label multicenter study in Brazil. Patients under age 18, or with associated systemic diseases, were excluded. Diagnosis was based on symptoms, otorhinolaryngological examination, and X-rays of the sinus. At the first visit, all patients were treated with a single daily dose of 400 mg gatifloxacin for 10 days. Middle nasal meatus secretion was collected and sent for culture before and after treatment. Patients were all reevaluated at days 3 to 5; days + 1 to + 5 and 18 to 25 days + 7 to + 14 . Ninety three percent of the patients were considered clinically cured at the end of the treatment. The most frequent bacteria isolated were Haemophilus influenzae, Streptococcus pneumoniae and Moraxella catarrhalis, and at the end of the treatment, presumed bacteriological eradication was observed in almost all patients. Adverse effects were observed in 19 of the cases, mostly mild and self limiting, including diarrhea, abdominal pain, nausea and vomiting. Treatment had to be interrupted in two cases. Gatifloxacin was found to be efficacious and safe for the treatment of acute rhinosinusitis in adults. en
dc.format.extent 162-168
dc.language.iso eng
dc.publisher Brazilian Society of Infectious Diseases
dc.relation.ispartof Brazilian Journal of Infectious Diseases
dc.rights Acesso aberto
dc.subject Rhinossinusitis en
dc.subject adults en
dc.subject gatifloxacin en
dc.title An open multicenter study of the use of gatifloxacin for the treatment of non-complicated acute bacterial rhinosinusitis in adults en
dc.type Artigo
dc.contributor.institution Federal University São Paulo Departament of Otolaryngology
dc.contributor.institution Santa Casa Misericórdia Medical School Dept. Otorhinolaryngology
dc.contributor.institution Universidade Estadual de Campinas (UNICAMP)
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Federal University São Paulo Departament of Otolaryngology
dc.description.affiliation Santa Casa Misericórdia Medical School Dept. Otorhinolaryngology
dc.description.affiliation University of Campinas Head Neck Surgery Dept. Otorhinolaryngology
dc.description.affiliation Federal University of São Paulo Division of Pediatric Otolaryngology
dc.description.affiliation Federal University of São Paulo Division of Pediatric Otolaryngology Fellow in Pediatric Otorhinolaryngology
dc.description.affiliationUnifesp UNIFESP, Division of Pediatric Otolaryngology
dc.description.affiliationUnifesp UNIFESP, Division of Pediatric Otolaryngology Fellow in Pediatric Otorhinolaryngology
dc.identifier.file S1413-86702005000200007.pdf
dc.identifier.scielo S1413-86702005000200007
dc.identifier.doi 10.1590/S1413-86702005000200007
dc.description.source SciELO



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