Seroprevalence of human herpesvirus 8 infection in children born to HIV-1- infected women in São Paulo, Brazil

Seroprevalence of human herpesvirus 8 infection in children born to HIV-1- infected women in São Paulo, Brazil

Author Machado, Daisy Maria Autor UNIFESP Google Scholar
Sumita, Laura Massami Google Scholar
Pannuti, Cláudio Sergio Google Scholar
Succi, Regina Célia de Menezes Autor UNIFESP Google Scholar
De Moraes-Pinto, Maria Isabel Autor UNIFESP Google Scholar
Souza, V.a.u.f. Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract Human herpesvirus-8 (HHV-8) appears to be transmitted mainly by sexual contact. However, several studies suggest that in developing countries the infection may be acquired early in life by routes other than sexual transmission. The present study estimated the seroprevalence of HHV-8 in Brazilian children born to HIV-1-infected mothers. The serum samples were collected in a cross-sectional cohort study from 99 children born to HIV-infected mothers (median age 3.27 years; range 1.5-13.8 years) attending the outpatient clinic of the Federal University of São Paulo. IgG antibodies to HHV-8 latency-associated nuclear antigen and lytic phase antigens were detected by immunofluorescence assays. The samples tested were collected from children aged 12 months or older to exclude the possibility of cross-placental antibody transport. The total prevalence of anti-lytic antibodies in this population (5/99; 5%) reveals that HHV-8 infection can occur during childhood. Children aged 1.5 to 2 years had a seroprevalence of 2% (1/50) and children aged 3.25 to 13.8 years had a seroprevalence of 8% (4/49). This difference was not statistically significant, probably because of the small size of the sample, but it suggests that HHV-8 infection occurs more commonly late in infancy. Further prospective studies are necessary to evaluate the timing and risk factors for primary HHV-8 infection in the pediatric population.
Keywords HHV-8
Seroprevalence
AIDS
Children
LANA-IFA
Lytic-IFA
Language English
Date 2005-02-01
Published in Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 38, n. 2, p. 237-240, 2005.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Associação Brasileira de Divulgação Científica
Extent 237-240
Origin http://dx.doi.org/10.1590/S0100-879X2005000200012
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000227480900012
SciELO ID S0100-879X2005000200012 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/2405

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