Bone mineral density of Brazilian girls with juvenile dermatomyositis

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dc.contributor.author Castro, Tania Caroline Monteiro de [UNIFESP]
dc.contributor.author Terreri, Maria Teresa Ramos Ascensão [UNIFESP]
dc.contributor.author Szejnfeld, Vera Lucia [UNIFESP]
dc.contributor.author Len, Claudio Arnaldo [UNIFESP]
dc.contributor.author Fonseca, A.s.m. da
dc.contributor.author Hilário, Maria Odete Esteves [UNIFESP]
dc.date.accessioned 2015-06-14T13:31:26Z
dc.date.available 2015-06-14T13:31:26Z
dc.date.issued 2005-02-01
dc.identifier http://dx.doi.org/10.1590/S0100-879X2005000200020
dc.identifier.citation Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 38, n. 2, p. 309-313, 2005.
dc.identifier.issn 0100-879X
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/2391
dc.description.abstract We measured bone mineral density (BMD) in girls with juvenile dermatomyositis (JDM) considering multiple factors in order to determine if it could be used as a predictor of reduction in bone mass. A cross-sectional study of lumbar spine BMD (L2-L4) was conducted on 10 girls aged 7-16 years with JDM. A group of 20 age-matched healthy girls was used as control. Lumbar spine BMD was measured by dual-energy X-ray absorptiometry. Weight, height and pubertal Tanner stage were determined in all patients and controls. Duration of disease and mean daily and cumulative steroid doses were calculated for all patients on the basis of their medical charts. JDM activity was determined on the basis of the presence of muscle weakness, cutaneous vasculitis and/or elevation of serum concentration of one or more skeletal muscle enzymes. Seven patients demonstrated osteopenia or osteoporosis. Lumbar BMD was significantly lower in the JDM patients than the age-matched healthy control girls (0.712 vs 0.878, respectively; Student t-test, P = 0.041). No significant correlation between BMD and age, height, Tanner stage, disease duration, corticosteroid use, or disease activity was observed in JDM girls, but a correlation was observed between BMD and weight (Pearson's correlation coefficient, r = 0.802). Patients with JDM may be at risk for a significant reduction in BMD that might contribute to further skeletal fragility. Our results suggest that reduced bone mass in JDM may be related to other intrinsic mechanisms in addition to steroid treatment and some aspects of the disease itself may contribute to this condition. en
dc.format.extent 309-313
dc.language.iso eng
dc.publisher Associação Brasileira de Divulgação Científica
dc.relation.ispartof Brazilian Journal of Medical and Biological Research
dc.rights Acesso aberto
dc.subject Dermatomyositis en
dc.subject Adolescent girls en
dc.subject Bone mineral density en
dc.subject Osteoporosis en
dc.subject Corticosteroids en
dc.title Bone mineral density of Brazilian girls with juvenile dermatomyositis en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade Federal do Rio Grande do Norte Departamento de Pediatria
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de Pediatria
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de Medicina Interna
dc.description.affiliation Universidade Federal do Rio Grande do Norte Departamento de Pediatria
dc.description.affiliationUnifesp UNIFESP, EPM, Depto. de Pediatria
dc.description.affiliationUnifesp UNIFESP, EPM, Depto. de Medicina Interna
dc.identifier.file S0100-879X2005000200020.pdf
dc.identifier.scielo S0100-879X2005000200020
dc.identifier.doi 10.1590/S0100-879X2005000200020
dc.description.source SciELO
dc.identifier.wos WOS:000227480900020



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