Improving survival among Brazilian children with perinatally-acquired AIDS

Improving survival among Brazilian children with perinatally-acquired AIDS

Author Matida, Luiza Harunari Autor UNIFESP Google Scholar
Marcopito, Luiz Francisco Autor UNIFESP Google Scholar
Succi, Regina Célia de Menezes Autor UNIFESP Google Scholar
Marques, Heloisa Helena de Souza Google Scholar
Della Negra, Marinella Google Scholar
Grangeiro, Alexandre Google Scholar
Hearst, Norman Google Scholar
Institution São Paulo State STD/AIDS Program
Universidade Federal de São Paulo (UNIFESP)
University of São Paulo
Infectious Disease Institute
National STD/AIDS Program
University of California
Abstract Brazil was the first developing country to provide free, universal access to antiretroviral treatment for AIDS patients. The Brazilian experience thus provides the first evidence regarding the impact of such treatment on the survival of perinatally acquired AIDS cases in the developing world. MATERIAL AND METHODS: This retrospective cohort study used medical record reviews to examine characteristics and trends in the survival of a representative sample of 914 perinatally acquired AIDS cases in 10 Brazilian cities diagnosed between 1983 and 1998. RESULTS: Survival time increased steadily and substantially. Whereas half of the children died within 20 months of diagnosis at the beginning of the epidemic, 75% of children diagnosed in 1997 and 1998 were still alive after four years of follow-up. CONCLUSIONS: Advances in management and treatment have made a great difference in the survival of Brazilian children with AIDS. These results argue strongly for making such treatment available to children in the entire developing world.
Keywords Acquired immunodeficiency syndrome
human immunodeficiency virus
perinatal transmission
Language English
Date 2004-12-01
Published in Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 8, n. 6, p. 419-423, 2004.
ISSN 1413-8670 (Sherpa/Romeo)
Publisher Brazilian Society of Infectious Diseases
Extent 419-423
Access rights Open access Open Access
Type Article
SciELO ID S1413-86702004000600005 (statistics in SciELO)

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