Acquired hemoglobin H disease in a patient with aplastic anemia evolving into acute myeloid leukemia

Acquired hemoglobin H disease in a patient with aplastic anemia evolving into acute myeloid leukemia

Alternative title Hemoglobinopatia H adquirida em um paciente com anemia aplástica e evolução para leucemia mielóide aguda
Author Figueiredo, Maria Stella Autor UNIFESP Google Scholar
Vicari, Perla Autor UNIFESP Google Scholar
Kimura, Eliza Yuriko Sugano Autor UNIFESP Google Scholar
Antunes, Sandra Vallin Autor UNIFESP Google Scholar
Yamamoto, Mihoko Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract CONTEXT: The prognosis of severe aplastic anemia has improved since the introduction of bone marrow transplantation and treatment with antithymocyte globulin. In contrast to the success of these protocols, studies with long term follow-up have shown the occurrence of clonal diseases such as paroxysmal nocturnal hemoglobinuria, myelodysplastic syndrome and acute leukemia in aplastic anemia. CASE REPORT: We report the first case of a Brazilian patient with aplastic anemia who developed myelodysplastic syndrome and acute myeloid leukemia showing acquired hemoglobin H and increased fetal hemoglobin.

CONTEXTO: O prognóstico da anemia aplástica grave melhorou com o advento do transplante de medula óssea e do tratamento imunossupressor com globulina antitimocitária. Em contraste com o sucesso destes protocolos, os estudos com seguimento a longo prazo mostraram a ocorrência de doenças clonais, tais como: hemoglobinúria paroxística noturna, síndrome mielodisplásica e leucemia aguda. RELATO DE CASO: Nós relatamos o primeiro caso descrito no Brasil de um paciente com anemia aplástica que evoluiu para síndrome mielodisplásica e leucemia mielóide aguda associada a presença de hemoglobina H e aumento da hemoglobina fetal.
Keywords Hemoglobin H
Disease
Aplastic anemia
Myeloid leukemia
Myelodysplastic syndromes
Doença
Hemoglobina H
Anemia aplástica
Leucemia mielóide
Síndromes mielodisplásicas
Language English
Date 2004-12-01
Published in São Paulo Medical Journal. Associação Paulista de Medicina - APM, v. 122, n. 6, p. 273-275, 2004.
ISSN 1516-3180 (Sherpa/Romeo)
Publisher Associação Paulista de Medicina - APM
Extent 273-275
Origin http://dx.doi.org/10.1590/S1516-31802004000600009
Access rights Open access Open Access
Type Article
SciELO ID S1516-31802004000600009 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/2296

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