Concentrações de vitaminas C e E em pacientes com ataxia telangiectasia: relação com biomarcadores associados a aterosclerose e ao estresse oxidativo.

Concentrações de vitaminas C e E em pacientes com ataxia telangiectasia: relação com biomarcadores associados a aterosclerose e ao estresse oxidativo.

Alternative title Concentrations of vitamins C and E in patients with ataxia telangiectasia: relationship to biomarkers associated whit atherosclerosis and oxidative stress
Author Andrade, Itana Gomes Alves Autor UNIFESP Google Scholar
Advisor Sarni, Roseli Oselka Saccardo Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Graduate program Pediatria e Ciências Aplicadas à Pediatria – São Paulo
Abstract Introdução: A ataxia telangiectasia (AT) e uma doenca neurodegenerativa, que cursa com imunodefiCiência em graus variaveis, disfuncao mitocondrial e exacerbacao do estresse oxidativo. Objetivo: avaliar o estado nutricional, perfil lipidico, peroxidacao lipidica e as concentracoes plasmaticas de vitaminas C e E e relaciona-las com biomarcadores associados ao risco de aterosclerose de pacientes com AT e controles. Metodos: Estudo transversal controlado envolvendo 13 pacientes e 22 controles saudaveis, pareados por genero e idade. Foram avaliados: estado nutricional, consumo alimentar, perfil lipidico e suas relacoes, concentracoes plasmaticas de vitaminas C e E, malondialdeido (MDA) e proteina C reativa ultrassensivel (PCRus). Resultados: A media de idade do grupo AT foi 14,6 anos; 4/13 (30,8%) eram desnutridos e 3/13 (23,1%) apresentavam baixa estatura para idade. Os pacientes apresentaram maior comprometimento de massa magra comparativamente aos controles. As concentracoes de triglicerides, colesterol total e de LDL-c foram significantemente mais elevadas nos pacientes e as de HDL-c, mais baixas. As relacoes associadas ao risco de aterosclerose (CT/HDL-c, LDL-c/HDL-c e Log TG/HDL-c) e o colesterol nao HDL (NHDL-c) foram significantemente superiores no grupo de pacientes em comparacao aos controles. Nao houve diferenca para as concentracoes de malondialdeido, proteina C reativa e de vitaminas C e E entre os dois grupos. As relacoes vitamina E/lipideos totais e vitamina E/triglicerides mostraram valores mais baixos no grupo de pacientes; correlacao significante e inversa entre estas relacoes e NHDL-c, CT/HDL-c, LDL-c/HDL-c e Log TG/HDL-c foi observada no grupo de pacientes. A alanina aminotransferase (ALT) correlacionou-se de forma direta e significante com NHDL-c, CT/HDL-c e LDL-c/HDL-c, no grupo de pacientes. A inGestão dietetica de energia, macronutrientes e de vitaminas C e E nao diferiu entre os grupos. Conclusao: O elevado risco aterosclerotico de pacientes com AT aliado ao comprometimento da defesa antioxidante e do estado nutricional pode complicar a evolucao da doenca e enfatiza a importancia da atencao multiprofissional com monitoramento de biomarcadores e orientacao nutricional apropriada

Introduction: Ataxia telangiectasia (AT) is a neurodegenerative disease that leads to immunodeficiency in varying degrees, mitochondrial dysfunction and oxidative stress. Objective: To evaluate the nutritional status, lipid profile, lipid peroxidation, and plasma concentrations of vitamins C and E and relate them with biomarkers associated with risk of atherosclerosis in patients with AT and controls. Methods: Cross sectional and controlled study involving 13 patients and 22 controls healthy, matched by gender and age. We evaluated: nutritional status, food intake, lipid profile and their relationships, plasma concentrations of vitamins C and E, malondialdehyde (MDA) and high-sensitivity C-reactive protein (hs CRP). Results: The mean age of the AT group was 14.6 years, 4/13 (30.8%) were malnourished and 3/13 (23.1%) had stunting. The patients showed greater impairment of lean body mass compared to controls. The concentrations of triglycerides, total cholesterol and LDL-c were significantly higher in patients and of HDL-c,lower. The ratios associated with the risk of atherosclerosis (TC/ HDL-c, and LDL-c/HDL-c Log TG / HDL-c) and non-HDL cholesterol (NHDL-c) were significantly higher in patients compared to controls. There was no difference in concentrations of malondialdehyde, C-reactive protein and vitamins C and E between the two groups. The ratios vitamin E / total lipids and vitamin E / triglycerides showed lower values in the group of patients; significant inverse between these ratiosand NHDL-c, TC/ HDL-c, and LDL-c/HDL-c Log TG / HDL -c was observed in the AT group. Alanine aminotransferase (ALT) correlated directly and significantly with NHDL-C, TC / HDL-c and LDL-c/HDL-c, in patients. Dietary intake of energy, macronutrients and vitamins C and E did not differ between groups. Conclusion: The high atherosclerotic risk of patients with AT coupled with impaired antioxidant defense and nutritional status may complicate the clinical course of the disease and emphasizes the importance of multidisciplinary care with monitoring of appropriate biomarkers and nutrition al guidance.
Keywords Ataxia Telangiectasia
Dislipidemias
Estresse Oxidativo
Ácido Ascórbico
Vitamina E
Estado Nutricional
Adolescente
Ataxia telangiectasia
dyslipidemia
oxidative stress
ascorbic acid
vitamin E
nutritional status
Humanos
Language Portuguese
Date 2013
Published in ANDRADE, Itana Gomes Alves. Concentrações de vitaminas C e E em pacientes com ataxia telangiectasia: relação com biomarcadores associados à aterosclerose e ao estresse oxidativo. 2013. 68 f. Dissertação (Mestrado em Ciências) – Escola Paulista de Medicina, Universidade Federal de São Paulo. São Paulo, 2013.
Publisher Universidade Federal de São Paulo (UNIFESP)
Extent 56 p.
Access rights Open access Open Access
Type Dissertation
URI http://repositorio.unifesp.br/handle/11600/22809

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