Effects of melatonin on the ovarian response to pinealectomy or continuous light in female rats: similarity with polycystic ovary syndrome

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dc.contributor.author Prata Lima, M.f.
dc.contributor.author Baracat, Edmund Chada [UNIFESP]
dc.contributor.author Simões, Manuel de Jesus [UNIFESP]
dc.date.accessioned 2015-06-14T13:31:11Z
dc.date.available 2015-06-14T13:31:11Z
dc.date.issued 2004-07-01
dc.identifier http://dx.doi.org/10.1590/S0100-879X2004000700007
dc.identifier.citation Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 37, n. 7, p. 987-995, 2004.
dc.identifier.issn 0100-879X
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/2155
dc.description.abstract The current study was conducted to investigate the relationship between melatonin and chronic anovulation. Adult (3-4 months old) female Wistar rats were submitted to pinealectomy: group I: pinealectomized ovariectomized melatonin-treated (N = 10); group II: pinealectomized ovariectomized placebo-treated (N = 12); group III: pinealectomized light-treated placebo-treated(N = 10) or maintained under continuous light; group IV: maintained under continuous light, ovariectomized melatonin-treated (N = 22); group V: maintained under continuous light, ovariectomized placebo-treated (N = 10); group VI: maintained under continuous light placebo-treated (N = 10). In order to assess ovarian modifications, unilateral ovariectomy was performed during the fourth month in groups I, II, IV, V and the other ovary was removed after 8 months. Ovariectomy was performed in groups III and VI only after eight months. Melatonin (200 µg/100 g body weight) dissolved in 0.02 ml absolute ethanol was injected intramuscularly daily during the last 4 months into groups I and IV. The other groups were treated with placebo (NaCl). The ovarian cysts were analyzed and their area, perimeter and maximum diameter, as well as the thickness of the ovarian capsule were measured. Daily colpocytological smears were performed throughout the study. Persistent estrous condition and ovarian cysts were observed in all groups. In pinealectomized rats the ovarian and vaginal alterations disappeared at the end of the study and in rats maintained under continuous light the vaginal and ovarian polycystic aspect was reversed only in those treated with melatonin. We conclude that melatonin may act on the ovarian response reverting chronic anovulation induced by pinealectomy or continuous light. en
dc.format.extent 987-995
dc.language.iso eng
dc.publisher Associação Brasileira de Divulgação Científica
dc.relation.ispartof Brazilian Journal of Medical and Biological Research
dc.rights Acesso aberto
dc.subject Melatonin en
dc.subject Polycystic ovary syndrome en
dc.subject Pineal body en
dc.subject Anovulation en
dc.title Effects of melatonin on the ovarian response to pinealectomy or continuous light in female rats: similarity with polycystic ovary syndrome en
dc.type Artigo
dc.contributor.institution Faculdade de Medicina do Triângulo Mineiro Disciplina de Ginecologia e Obstetrícia
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Faculdade de Medicina do Triângulo Mineiro Disciplina de Ginecologia e Obstetrícia
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de Ginecologia
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de Histologia
dc.description.affiliationUnifesp UNIFESP, EPM, Depto. de Ginecologia
dc.description.affiliationUnifesp UNIFESP, EPM, Depto. de Histologia
dc.identifier.file S0100-879X2004000700007.pdf
dc.identifier.scielo S0100-879X2004000700007
dc.identifier.doi 10.1590/S0100-879X2004000700007
dc.description.source SciELO
dc.identifier.wos WOS:000222450200007



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