Prevalence of codon 72 P53 polymorphism in Brazilian women with cervix cancer

Prevalence of codon 72 P53 polymorphism in Brazilian women with cervix cancer

Author Brenna, Sylvia Michelina Fernandes Google Scholar
Silva, Ismael Dale Cotrim Guerreiro da Autor UNIFESP Google Scholar
Zeferino, Luiz Carlos Google Scholar
Pereira, Julia Santucci Autor UNIFESP Google Scholar
Martinez, Edson Zachaione Google Scholar
Syrjänen, Kari Juhani Google Scholar
Institution Hospital Maternidade Leonor Mendes de Barros Oncologia Ginecológica
Universidade Federal de São Paulo (UNIFESP)
Universidade Estadual de Campinas (UNICAMP)
Universidade de São Paulo (USP)
Istituto Superiore di Sanità Laboratory of Epidemiology and Biostatistics Cytopathology Unit
Abstract The p53 codon 72 polymorphism seems to be associated with HPV-carcinogenesis, although controversial data have been reported. A series of Brazilian women with cervix carcinomas were analyzed. Ninety-nine (67%) of 148 women were found to be homozygous (arg/arg) for the arginine polymorphism, and 49 (33%) were heterozygous (arg/pro). This polymorphism may be an important determinant of the risk for cervix cancer, but does not seem to be sufficient for carcinogenesis.
Keywords p53 polymorphism
codon 72
genetic polymorphism
cervix cancer
human papillomavirus
Language English
Date 2004-01-01
Published in Genetics and Molecular Biology. Sociedade Brasileira de Genética, v. 27, n. 4, p. 496-499, 2004.
ISSN 1415-4757 (Sherpa/Romeo, impact factor)
Publisher Sociedade Brasileira de Genética
Extent 496-499
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000226583400004
SciELO ID S1415-47572004000400005 (statistics in SciELO)

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