Hormone replacement therapy increases levels of antibodies against heat shock protein 65 and certain species of oxidized low density lipoprotein

Hormone replacement therapy increases levels of antibodies against heat shock protein 65 and certain species of oxidized low density lipoprotein

Author Uint, Luciana Google Scholar
Gebara, Otávio Celso Eluf Google Scholar
Pinto, Lígia B. Google Scholar
Wajngarten, Maurício Google Scholar
Boschcov, Paulo Autor UNIFESP Google Scholar
Luz, Protásio Lemos da Google Scholar
Gidlund, Magnus Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract Hormone replacement therapy (HRT) reduces cardiovascular risks, although the initiation of therapy may be associated with transient adverse ischemic and thrombotic events. Antibodies against heat shock protein (Hsp) and oxidized low density lipoprotein (LDL) have been found in atherosclerotic lesions and plasma of patients with coronary artery disease and may play an important role in the pathogenesis of atherosclerosis. The aim of the present study was to assess the effects of HRT on the immune response by measuring plasma levels of antibodies against Hsp 65 and LDL with a low and high degree of copper-mediated oxidative modification of 20 postmenopausal women before and 90 days after receiving orally 0.625 mg equine conjugate estrogen plus 2.5 mg medroxyprogesterone acetate per day. HRT significantly increased antibodies against Hsp 65 (0.316 ± 0.03 vs 0.558 ± 0.11) and against LDL with a low degree of oxidative modification (0.100 ± 0.01 vs 0.217 ± 0.02) (P<0.05 and P<0.001, respectively, ANOVA). The hormone-mediated immune response may trigger an inflammatory response within the vessel wall and potentially increase plaque burden. Whether or not this immune response is temporary or sustained and deleterious requires further investigation.
Keywords Hormone replacement therapy
Postmenopause
Oxidized LDL
Heat shock protein
Immune response
Antibodies
Language English
Date 2003-04-01
Published in Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 36, n. 4, p. 491-494, 2003.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Associação Brasileira de Divulgação Científica
Extent 491-494
Origin http://dx.doi.org/10.1590/S0100-879X2003000400011
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000182664000011
SciELO ID S0100-879X2003000400011 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/1707

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