Bone mineral density in juvenile systemic lupus erythematosus

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dc.contributor.author Castro, Tania Caroline Monteiro de [UNIFESP]
dc.contributor.author Terreri, Maria Teresa Ramos Ascensão [UNIFESP]
dc.contributor.author Szejnfeld, Vera Lucia [UNIFESP]
dc.contributor.author Castro, Charlles Heldan de Moura [UNIFESP]
dc.contributor.author Fisberg, Mauro [UNIFESP]
dc.contributor.author Gabay, M. [UNIFESP]
dc.contributor.author Hilário, Maria Odete Esteves [UNIFESP]
dc.date.accessioned 2015-06-14T13:29:48Z
dc.date.available 2015-06-14T13:29:48Z
dc.date.issued 2002-10-01
dc.identifier http://dx.doi.org/10.1590/S0100-879X2002001000008
dc.identifier.citation Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 35, n. 10, p. 1159-1163, 2002.
dc.identifier.issn 0100-879X
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/1529
dc.description.abstract We evaluated spine bone mineral density (BMD) in Brazilian children with juvenile systemic lupus erythematosus (JSLE) in order to detect potential predictors of reduction in bone mass. A cross-sectional study of BMD at the lumbar spine level (L2-L4) was conducted on 16 female JSLE patients aged 6-17 years. Thirty-two age-matched healthy girls were used as control. BMD at the lumbar spine was measured by dual-energy X-ray absorptiometry. Weight, height and pubertal Tanner stage were determined in patients and controls. Disease duration, mean daily steroid doses, mean cumulative steroid doses and JSLE activity measured by the systemic lupus erythematosus disease activity index (SLEDAI) were determined for all JSLE patients based on their medical charts. All parameters were used as potential determinant factors for bone loss. Lumbar BMD tended to be lower in the JSLE patients, however, this difference was not statistically significant (P = 0.10). No significant correlation was observed in JSLE girls between BMD and age, height, Tanner stage, disease duration, corticosteroid use or disease activity. We found a weak correlation between BMD and weight (r = 0.672). In the JSLE group we found no significant parameters to correlate with reduced bone mass. Disease activity and mean cumulative steroid doses were not related to BMD values. We did not observe reduced bone mass in female JSLE. en
dc.format.extent 1159-1163
dc.language.iso eng
dc.publisher Associação Brasileira de Divulgação Científica
dc.relation.ispartof Brazilian Journal of Medical and Biological Research
dc.rights Acesso aberto
dc.subject Systemic lupus erythematosus en
dc.subject Children en
dc.subject Adolescents en
dc.subject Bone mineral density en
dc.subject Osteoporosis en
dc.subject Corticosteroids en
dc.title Bone mineral density in juvenile systemic lupus erythematosus en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de Pediatria
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de Medicina
dc.description.affiliationUnifesp UNIFESP, EPM, Depto. de Pediatria
dc.description.affiliationUnifesp UNIFESP, EPM, Depto. de Medicina
dc.identifier.file S0100-879X2002001000008.pdf
dc.identifier.scielo S0100-879X2002001000008
dc.identifier.doi 10.1590/S0100-879X2002001000008
dc.description.source SciELO
dc.identifier.wos WOS:000179717000008



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