Bone mineral density in juvenile systemic lupus erythematosus

Bone mineral density in juvenile systemic lupus erythematosus

Author Castro, Tania Caroline Monteiro de Autor UNIFESP Google Scholar
Terreri, Maria Teresa Ramos Ascensão Autor UNIFESP Google Scholar
Szejnfeld, Vera Lucia Autor UNIFESP Google Scholar
Castro, Charlles Heldan de Moura Autor UNIFESP Google Scholar
Fisberg, Mauro Autor UNIFESP Google Scholar
Gabay, M. Autor UNIFESP Google Scholar
Hilário, Maria Odete Esteves Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract We evaluated spine bone mineral density (BMD) in Brazilian children with juvenile systemic lupus erythematosus (JSLE) in order to detect potential predictors of reduction in bone mass. A cross-sectional study of BMD at the lumbar spine level (L2-L4) was conducted on 16 female JSLE patients aged 6-17 years. Thirty-two age-matched healthy girls were used as control. BMD at the lumbar spine was measured by dual-energy X-ray absorptiometry. Weight, height and pubertal Tanner stage were determined in patients and controls. Disease duration, mean daily steroid doses, mean cumulative steroid doses and JSLE activity measured by the systemic lupus erythematosus disease activity index (SLEDAI) were determined for all JSLE patients based on their medical charts. All parameters were used as potential determinant factors for bone loss. Lumbar BMD tended to be lower in the JSLE patients, however, this difference was not statistically significant (P = 0.10). No significant correlation was observed in JSLE girls between BMD and age, height, Tanner stage, disease duration, corticosteroid use or disease activity. We found a weak correlation between BMD and weight (r = 0.672). In the JSLE group we found no significant parameters to correlate with reduced bone mass. Disease activity and mean cumulative steroid doses were not related to BMD values. We did not observe reduced bone mass in female JSLE.
Keywords Systemic lupus erythematosus
Children
Adolescents
Bone mineral density
Osteoporosis
Corticosteroids
Language English
Date 2002-10-01
Published in Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 35, n. 10, p. 1159-1163, 2002.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Associação Brasileira de Divulgação Científica
Extent 1159-1163
Origin http://dx.doi.org/10.1590/S0100-879X2002001000008
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000179717000008
SciELO ID S0100-879X2002001000008 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/1529

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