Use of single photon emission computed tomography and magnetic resonance to evaluate central nervous system involvement in patients with juvenile systemic lupus erythematosus

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dc.contributor.author Prismich, Glaucia [UNIFESP]
dc.contributor.author Hilário, Maria Odete Esteves [UNIFESP]
dc.contributor.author Len, Claudio Arnaldo [UNIFESP]
dc.contributor.author Terreri, Maria Teresa Ramos Ascensão [UNIFESP]
dc.contributor.author Quaresma, Marina Rodrigues [UNIFESP]
dc.contributor.author Alonso, Gilberto [UNIFESP]
dc.contributor.author Sevillano, Marta Maite [UNIFESP]
dc.contributor.author Lederman, Henrique Manoel [UNIFESP]
dc.date.accessioned 2015-06-14T13:29:45Z
dc.date.available 2015-06-14T13:29:45Z
dc.date.issued 2002-07-01
dc.identifier http://dx.doi.org/10.1590/S0100-879X2002000700007
dc.identifier.citation Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 35, n. 7, p. 805-810, 2002.
dc.identifier.issn 0100-879X
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/1477
dc.description.abstract The objective of the present study was to identify the single photon emission computed tomography (SPECT) and magnetic resonance (MR) findings in juvenile systemic lupus erythematosus (JSLE) patients with CNS involvement and to try to correlate them with neurological clinical history data and neurological clinical examination. Nineteen patients with JSLE (16 girls and 3 boys, mean age at onset 9.2 years) were submitted to neurological examination, electroencephalography, cerebrospinal fluid analysis, SPECT and MR. All the evaluations were made separately within a period of 15 days. SPECT and MR findings were analyzed independently by two radiologists. Electroencephalography and cerebrospinal fluid analysis revealed no relevant alterations. Ten of 19 patients (53%) presented neurological abnormalities including present or past neurological clinical history (8/19, 42%), abnormal neurological clinical examination (5/19, 26%), and abnormal SPECT or MR (8/19, 42% and 3/19, 16%, respectively). The most common changes in SPECT were cerebral hypoperfusion and heterogeneous distribution of blood flow. The most common abnormalities in MR were leukomalacia and diffuse alterations of white matter. There was a correlation between SPECT and MR (P<0.05). We conclude that SPECT and MR are complementary and useful exams in the evaluation of neurological involvement of lupus. en
dc.format.extent 805-810
dc.language.iso eng
dc.publisher Associação Brasileira de Divulgação Científica
dc.relation.ispartof Brazilian Journal of Medical and Biological Research
dc.rights Acesso aberto
dc.subject Systemic lupus erythematosus en
dc.subject Central nervous system en
dc.subject Single photon emission computed tomography en
dc.subject Magnetic resonance en
dc.subject Neurological clinical history en
dc.title Use of single photon emission computed tomography and magnetic resonance to evaluate central nervous system involvement in patients with juvenile systemic lupus erythematosus en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP) Departamento de Pediatria Divisão de Alergia, Imunologia Clínica e Reumatologia
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP) Departamento de Diagnóstico por Imagem Divisão de Medicina Nuclear
dc.description.affiliationUnifesp UNIFESP, Depto. de Pediatria Divisão de Alergia, Imunologia Clínica e Reumatologia
dc.description.affiliationUnifesp UNIFESP, Depto. de Diagnóstico por Imagem Divisão de Medicina Nuclear
dc.identifier.file S0100-879X2002000700007.pdf
dc.identifier.scielo S0100-879X2002000700007
dc.identifier.doi 10.1590/S0100-879X2002000700007
dc.description.source SciELO
dc.identifier.wos WOS:000177456600007



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