Proteinase activity regulation by glycosaminoglycans

Proteinase activity regulation by glycosaminoglycans

Author Tersariol, Ivarne Luis dos Santos Autor UNIFESP Google Scholar
Pimenta, D.c. Autor UNIFESP Google Scholar
Chagas, Jair Ribeiro Autor UNIFESP Google Scholar
Almeida, P.c. Google Scholar
Institution Universidade de Mogi das Cruzes Centro Interdisciplinar de Investigação Bioquímica
Universidade Federal de São Paulo (UNIFESP)
Abstract There are few reports concerning the biological role and the mechanisms of interaction between proteinases and carbohydrates other than those involved in clotting. It has been shown that the interplay of enzymes and glycosaminoglycans is able to modulate the activity of different proteases and also to affect their structures. From the large number of proteases belonging to the well-known protease families and also the variety of carbohydrates described as widely distributed, only few events have been analyzed more deeply. The term family is used to describe a group of proteases in which every member shows an evolutionary relationship to at least one other protease. This relationship may be evident throughout the entire sequence, or at least in that part of the sequence responsible for catalytic activity. The majority of proteases belong to the serine, cysteine, aspartic or metalloprotease families. By considering the existing limited proteolysis process, in addition to the initial idea that the proteinases participate only in digestive processes, it is possible to conclude that the function of the enzymes is strictly limited to the cleavage of intended substrates since the destruction of functional proteins would result in normal tissue damage. In addition, the location as well as the eventual regulation of protease activity promoted by glycosaminoglycans can play an essential role in the development of several physiopathological conditions.
Keywords Proteinases
Heparin binding
Language English
Date 2002-02-01
Published in Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 35, n. 2, p. 135-144, 2002.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Associação Brasileira de Divulgação Científica
Extent 135-144
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000174281400001
SciELO ID S0100-879X2002000200001 (statistics in SciELO)

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